Our Mission
Pipeline
Our Focus
We are advancing a wholly owned portfolio of oral small molecule GPCR-targeted programs focused initially on treating patients with significant unmet needs in endocrinology, immunology and inflammation, and metabolic disease.
For each program, we utilize our Native Complex Platform™ to discover a diverse portfolio of small molecules with mechanisms of action designed to have disease-modifying potential and with distinct chemical properties. We have prioritized programs that offer biomarker-driven strategies for early clinical readouts.
Pipeline
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Wholly-Owned Programs
Development Status
Program / Target
Mode of Action
Therapeutic Area
Indications / US Patient Population
Discovery
IND-enabling
Phase 1
Phase 2
PTH1R Program
Hypoparathyroidism
40%
SEP-631 (MRGPRX2)
Chronic spontaneous urticaria
Other mast cell diseases
50%
TSHR Program
Graves' disease
Thyroid eye disease
20%
Research Areas:
20%
Partnered Programs
Partner
The Details
Programs
Additional Information

PTH1R Program
Oral small molecule agonist targeting PTH1R for the treatment of hypoparathyroidism that could offer a convenient, functional replacement for PTH for all hypoparathyroidism patients.

SEP-631 (MRGPRX2)
Oral small molecule negative allosteric modulator (NAM) that inhibits MRGPRX2 and could provide a differentiated treatment option for patients with chronic spontaneous urticaria (CSU) and other mast cell driven diseases.

TSHR Program
Oral small molecule thyroid-stimulating hormone receptor (TSHR) NAM that could offer a novel disease-modifying treatment approach for both Graves’ Disease and Thyroid Eye Disease.
The Details
Publications
